nci-c55107[qr]
2-Chloroacetophenone
CAS: 532-27-4
Molecular Formula: C8H7ClO
nci-c55107[qr] - Names and Identifiers
| Name | 2-Chloroacetophenone |
| Synonyms | phenacyl nci-c55107[qr] 2-Chloroacetophenone phenacylchloride[qr] α-chloroacetophenone 2-Chloro acetophenone phenylchloromethylketone Phenyl chloromethyl ketone -Phenyl-2-chloro-1-ethanone omega-chloroacetophenone[qr] phenacylchloride(2-chloroacetophenone) |
| CAS | 532-27-4 |
| EINECS | 208-531-1 |
| InChI | InChI=1/C8H7ClO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2 |
| InChIKey | IMACFCSSMIZSPP-UHFFFAOYSA-N |
nci-c55107[qr] - Physico-chemical Properties
| Molecular Formula | C8H7ClO |
| Molar Mass | 154.59 |
| Density | 1.188 |
| Melting Point | 52-56℃ |
| Boling Point | 244-245℃ |
| Flash Point | 118℃ |
| Water Solubility | insoluble. <0.1 g/100 mL at 19℃ |
| Vapor Presure | 4 at 20 °C, 14 at 30 °C (quoted, Verschueren, 1983) |
| Appearance | Morphological Colorless crystals |
| Stability | May decompose upon exposure to air or water. Incompatible with bases, amines, alcohols. |
| Refractive Index | 1.5438 |
| Physical and Chemical Properties | Density 1.188 melting point 52-56°C boiling point 244-245°C flash point 118°C refractive index 1.5438 water-soluble insoluble. <0.1g/100 mL at 19°C |
| Use | Used as pharmaceutical intermediates for pharmaceutical and for organic synthesis |
nci-c55107[qr] - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R23/25 - Toxic by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1697 |
| WGK Germany | 3 |
| RTECS | AM6300000 |
| FLUKA BRAND F CODES | 9-19 |
| TSCA | Yes |
| Hazard Class | 6.1 |
| Packing Group | II |
| Toxicity | LD50 in rats (mg/kg): 41 i.v., 36 i.p., 127 orally; LC50 in rats: 8750 mg/min/m3 (Ballantyne, Swanston) |
nci-c55107[qr] - Upstream Downstream Industry
nci-c55107[qr] - Nature
Open Data Verified Data
white or pale yellow crystals with a relative density of 1. 324. Melting point 54 C (56.5 C). Boiling point 244~245 ℃,139~141 ℃(1. 86kPa). Insoluble in water, soluble in ether, ethanol, chloroform, benzene, etc. Steam distillation can be performed.
Last Update：2024-01-02 23:10:35
nci-c55107[qr] - Preparation Method
Open Data Verified Data
There are two ways.
- acetophenone chloride method acetophenone is pumped into the reaction kettle, chlorine gas is introduced, and the reaction is carried out at 60~80 ℃ until the chlorine gas reaches the theoretical amount, and the low boiling substance is distilled off under reduced pressure, the mixture was cooled to below 5 ° C., allowed to stand, crystals were precipitated, and the product was obtained by filtration.
- Chloroacetyl Chloride method dichlorosulfoxide is added to chloroacetic acid, stirring reflux, distilling out the crude product, mixing it with carbon disulfide, slowly adding to the mixture of benzene, anhydrous aluminum trichloride and carbon disulfide, keep the temperature below 30 ℃, refluxing with heat after adding, let stand, pour into ice water and dilute hydrochloric acid solution, filter and blow dry, crystallize with dilute ethanol, and obtain the product by distillation under reduced pressure.
Last Update：2022-01-01 10:42:41
nci-c55107[qr] - Use
Open Data Verified Data
This product is used in organic synthesis, in medicine for the synthesis of hydrochloric acid four imidazole and so on.
Last Update：2022-01-01 10:42:41
nci-c55107[qr] - Safety
Open Data Verified Data
by high heat points to explain the release of toxic gases. Toxic and corrosive gases are released from contact with water or steam. Highly corrosive articles. Toxic. It's a tear-inducing military agent. Rat oral LD50:50mg/kg. Strong irritation and corrosive to the eyes, skin and mucous membranes.
Last Update：2022-01-01 10:42:42
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Product Name: 2-Chloroacetophenone Request for quotationCAS: 532-27-4
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: 2-Chloroacetophenone Request for quotation
CAS: 532-27-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 532-27-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
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